Tor 26 maj / År 40 / Nr 1 2022

SymCel introduces multi-channel calorimetric system developed for cell based assays

Swedish biotechnology company SymCel has spent the past six years developing novel cell screening tools based on established calorimetry science. Today, SymCel operates with over 30 years of experience originating from various disciplines within the biotechnology industry as well as the pharmaceutical development industry. This fall, the company aims at introducing a revolutionary product within the biotechnology field; a multi-channel calorimetric system developed for cell based assays.

Both commercial and academic research environments have an unmet need for fast, reliable and manageable monitoring of cell metabolism, and a continuous screening of cells to provide real-time data. Current methods involve several tests done separately, but SymCel has developed an instrument capable of running several tests in parallel, providing a continuous stream of data.
“The advantages are numerous. The technology enables for multiple testing using a limited number of cells. The instrument is called calScreener, and is capable of measuring up to 32 different samples simultaneously, measuring heat emanating from the cell metabolism without using additives”, Marketing Manager Magnus Jansson explains.
The technology does not require extensive knowledge of pathways and specific target functions, providing a large freedom in designing the experiment. Similar tests have previously been conducted by calorimetry experts. The calScreener, however, enables for a large number of trained laboratory staff to handle the testing equipment and obtaining reliable results without prior knowledge in the specific field of calorimetry.

Market introduction this fall
The calScreener is the first available multi-channel calorimetric system developed specifically for cell based assays. Measurement of heat flux in living cells is an established and proven technology to monitor changes in metabolic processes. The technology has now reached its final development stage, and SymCel are aiming for a market introduction this fall.
“The technology complements existing instruments and technologies available to life science and biotechnology laboratories today. It provides researchers with a novel tool to measure the cellular metabolic response in a native environment providing insights not possible using other methods”, Magnus Jansson continues.
Based on the measurement of thermogenic response in cultivated cells, as previously discussed, the calScreener requires no addition of substrates and not necessary knowledge of the specific pathway or target. Hence, the time it takes to obtain results is greatly reduced as well as the cost for obtaining data.

Developed to suit a wide range of applications
The calScreener has been developed to suit a wide range of cell-science applications. It can for example be used as a screening tool applicable to a large number of biological systems where any types of cultivated cells as well as bacterial cultures are possible to use.
The instrument can thus be used for several types of applications where changes in metabolic rate of the cells are expected, like for example compound screening, lead substance optimisation, bioavailability studies, cellular toxicity studies, biopharmaceutical process optimisation, and antibiotics development.
“Our technology meets an actual need in both commercial and academic laboratories. Our potential market is global, and we hope to establish further collaborations with biotech and pharmaceutical companies as well as universities and research institutes worldwide”, Magnus Jansson concludes.